Conference Programs
September 18th - Short Course/Workshops | 19th, 20th and 21st - Main Conference
Pre-conference Workshop/Short Course
Three Parellel Programs Download Pre-conference ScheduleShort Course on
Drug Metabolism, Transporters and Toxicology
at JN Tata Auditorium, IISc., Bangalore
Breakfast
Introduction to Metabolism: Phase I, II reactions
(focused on reaction mechanisms)
Prof. Krishna Iyer
Professor of Pharmaceutical Chemistry
Bombay College of Pharmacy, Mumbai
Tea Break (15 min)
Drug Drug Interactions - Basic concepts and Assessment
Dr. Mike Sinz,
Bristol Myers Squibb.
Princeton, USA
Lunch (1 hour)
Introduction to drug transporters and their role in drug disposition
Dr. Bhagwat Prasad,
Washington State University,
USA
Tea Break (15 min)
Basic Concepts of Toxicology
Dr. Myrtle Davis,
Bristol Myers Squibb.
Princeton, USA
Workshop on Microsampling and Mass Spectrometry
at Prof. Utpal Tatu’s Lab, IISc., Bangalore
Scope:
Workshop will provide practical training on
- application of mass spectrometry in field of DMPK. It includes basics of mass spectrometry, training on sample preparation, method development and data analysis
- know-hows of microsampling methodologies and Dried Matrix Sample bioanalysis in pre-clinical PK/TK/efficacy studies
Venue:
Prof. Utpal Tatu's lab
FB-03, Department of Biochemistry
New Biological Science Building
Indian Institute of Science, Bangalore, 560012
Organizing committee members:
Priyadeep Bhutani,
Prashant Kole and
Mallikarjun
Breakfast
Inauguration
A lecture on Serial microsampling in rodent species: Serial sampling sites, procedures, sampling volumes, sample handling, Sample collection cards, spotting technique, sample storage and transfer
Dr. Prashant Kole,
BBRC, Syngene International Ltd.
Bangalore
Tea Break (15 min)
Understanding on Hardware and Software (Data acquisition and processing) of Mass Spectrometry
Mallikarjun,
IISc, Bangalore
Lunch (1 hour)
Calibration, Sample Preparation and Method Development
Mallikarjun,
IISc, Bangalore
Data Analysis and Interpretation
Mallikarjun,
IISc, Bangalore
Demonstration of Nanotemper products
Dr. Sivaramaiah Nallapeta,
NanoTemper
Question & Answers
Workshop on Pharmaceutical Modeling and Simulation (PuMaS) Software
at JN Tata Auditorium, IISc, Bangalore
By: Dr. Vijay Ivaturi, University of Maryland, USA
Organizing Committee Members: Devang Shah and Vishwanath KM
Abstract:
Pharmacometrics is the practice of using mathematical models for decision making in drug development and clinical therapeutics. In this day-long workshop, participants will be introduced to PuMaS (Pharmaceutical Modeling and Simulation).
PuMaS is a domain-specific extension of the Julia differential equation solver libraries for performing analyses of pharmacometric models. We will start by showing users how to implement PK/PD models with complex dosing schedules and incorporating population models. Then we will turn to the process of estimating population parameters from data. Next, the capability of PuMaS to perform common pre-clinical and clinical data analytics workflows such as Non-compartmental analysis (NCA), In vitro- in vivo correlation (IVIVC), Bioequivalence (BE) and Clinical Trial Design (CTS) will be introduced.
This workshop will be a mix of demonstration and hands-on work where participants will be able to download the PuMaS software and perform the analysis in real-time. At the end of the workshop, participants will have an overview of the PuMaS toolkit and its utility in modern age computing.
Breakfast
Registration
Introduction
Tea Break (15 min)
PuMaS software
Lunch (1 hour)
PuMaS software (Contd…)
Tea Break (15 min)
PuMaS software (Contd…)
Note: All attendees will be responsible for bringing their own laptop computers
Main Conference at JN Tata Auditorium, IISc, Bangalore
Download Main-conference ScheduleTitle of Presentation
Speaker, Organization
Inagural Session
Registration and Breakfast
Opening Remarks
T. Thanga Mariappan,
President- SSX, India
BBRC, Syngene International Ltd.,
Bangalore.
SSX Logo Unveiling
Vinay H.K.,
Secretary- SSX, India
BBRC, Syngene International Ltd.,
Bangalore.
Conference Inauguration
Lois.Lehman-McKeeman, (BMS, USA),
Jasminder Sahi, (Sanofi, China),
Bill Smith, (Gilead, USA),
Yuichi Sugiyama, (RIKEN, Japan)
Utpal Tatu, (IISc, India)
T. Thanga Mariappan, (SSX, India)
Plenary Lecture 1:
Quantitative prediction of the hepatic clearance and complex drug interactions using extended clearance concept and PBPK with in vitro transporter/enzyme data
Dr. Yuichi Sugiyama,
RIKEN, Japan
Co-chair: Jasminder Sahi,
Sanofi, China
Session 1: Drug Metabolism and DDI
Co-Chairs: Bill Smith, Gilead, USA,
Rama Sivasubramanian, Novartis, India
Solving Biotransformation Challenges: Beyond P450 enzymes Cyrus
Khojasteh
Genentech USA
Group Photo
Tea Break (1040-1100)
Ocular Drug Metabolism
Upendra Argikar,
Novartis, USA
The Constitutive Androstane Receptor (CAR) and Enzyme Induction
Mike Sinz,
BMS, USA
Sponsor Talk – I (Solvo)
Sponsor Talk -II (Syngene)
ADME driven clinical candidate optimization in integrated drug discovery: Case studies from Syngene
Vishwottam Kandikere,
Syngene International Ltd., India
Young Investigator Presentation-I
Predictive analysis of the intestinal bioavailability using in-house built mechanistic oral absorption model
Aarzoo Thakur,
NIPER- Mohali, India
Young Investigator Presentation-II
Investigation of Inflammatory Biomarkers for Neurodegeneration Based on Computational Network Based Approaches
Sneha Yadav, AMITY Institute of Biotechnology,
Lucknow, India
Panel Discussion
Lunch (1315-1400)
Poster Session (Posters 1 to 40)
Session 2: Drug Transporters and Disposition
Co-Chairs: Yuichi Sugiyama, RIKEN, Japan,
Sagnik Chatterjee, BBRC, Syngene International Ltd., India
Confidence in Translation: A case study of a complex human PK prediction of an integrin antagonist
Bill Smith,
Gilead, USA
Interplay of efflux transport and metabolism: Is one more important than another in enterohepatic recycling of drugs?
Bhagwat Prasad,
Washington State University, USA
Tea Break(1610-1625)
3D Spheroid Models for In Vitro Toxicity Testing
Roxana Ghadessy,
Corning Life Sciences, Singapore
Characterization of hepatobiliary transport of a bile acid and organic anions in vitro to identify the rate-determining process; Use of doubly transfected cell line systems
Sumito Ito,
Genomembrane
Sponsor Talk-III
Microflow Data Update and Overview of the Echo MS System
Rolf Kern,
AB Sciex
Panel Discussion
Reception (by Invitation only)
assemble at the entrance of JN Tata Auditorium
Travel to Courtyard by Marriott(1820-1850)
Reception at Courtyard by Marriott, Hebbal
Title of Presentation
Speaker, Organization
Breakfast
Plenary Lecture 2
Toxicology in Drug Discovery and Development: Methods, Models and Mechanisms
Lois.Lehman-McKeeman, BMS, USA
Co-Chair: Sandhya Mandlekar,
BBRC, India
Session sponsored by GVK Bio, Hyderabad
Session 3: Toxicological Issues Encountered in Drug Discovery and Development
Co-Chairs: Lois.Lehman-McKeeman, BMS, USA,
Anandi Karumbati, CCBT, inStem, India
Ecotoxicological Modeling of Contaminants of Emerging Concern (CECs) Using Quantitative Structure-Activity Relationship (QSAR) Approaches: A Few Case Studies
Kunal Roy,
Jadavpur University, India
Novel Developmental And Reproductive Toxicity Methods
Kesava Cuddapah,
Curio Biotech, Switzerland
Tea Break (1040-1100)
Xenobiotic compounds: How it modifies glucose milieu?
Ramasamy Subbiah,
Madurai Kamaraj University, India
Young investigator presentation-III
Mechanism-based PBPK modeling of pemafibrate to describe drug-drug interactions with cyclosporine and rifampicin
Ji Eun Park,
Sugiyama Laboratory, Japan
Sponsor Talk-IV
Drug Polymorphism: Impact on Pharmacokinetics
Pratima Srivastava,
GVK Bio, Hyderabad, India
Panel Discussion
Lunch (1220-1300)
Poster Session (Posters 41 to 80)
Parallel
Sessions
Session 4:
Modelling and Simulation
Co-Chairs: Surulivel Rajan, Manipal University, India,
Manasa Deepa, East West College of Pharmacy, Bangalore
Session 5:
New Tools/Technologies
Co-Chairs: Vamsi Madugula, Syngene International Ltd, India,
Amol Raje, Eurofins, Bangalore
Seminar Hall A
Main Auditorium
Pharmacometrics as a decision making toolkit in drug development and clinical therapeutics
Vijay Ivaturi,
University of Maryland, USA
Novel hepatic and enteric experimental systems for the evaluation of drug metabolism, drug-drug interactions, and drug toxicity
Albert Li,
In Vitro ADMET, USA
Drug Metabolites as Inhibitors: Translation to the Clinic Using Modeling and Simulation
Jan Wahlstrom,
Amgen, USA
HepaRG® : In vitro tool to study Drug Metabolism and Hepatotoxicity in the Pharmaceutical Industry
Ashwani Sharma,
Biopredic, France
Pharmacokinetic guided drug discovery and development
Rabi Bhatta,
CDRI, India
Characterization of Metabolizing Enzymes in Human Skin and Reconstructed Human Skin Models from SkinEthic(TM)
Joan Eilstein,
Loreal, India
Tea Break (1545-1600)
Session 6: Special Session for Students
Co-Chairs: Arti Thakkar, Amity University, India,
Anoop Kumar, BBRC, Syngene International Ltd., India
New Drug Discovery & Development in the Era of 4th Industrial Revolution: Excitement, Opportunities and Challenges
Prof. Ramesh K. Goyal,
Vice Chancellor, DPSRU, India
Introduction: Vinay H.K.,
Syngene International Ltd., India
Special Panel Discussion for Students
Moderators:
Arti Thakkar and Sandhya Subhash
Program by Students from East West College of Pharmacy, Bangalore
Moderator:
Manasa Deepa
DJ
High Tea / Networking (1845-1915)
Title of Presentation
Speaker, Organization
Session 7: Case Studies in Drug Discovery
Co-Chairs: Jasminder Sahi, Sanofi, China,
Vinay HK, BBRC, Syngene International Ltd., India
Breakfast
"When you come to a fork in the road, take it" my experiences as a DMPK scientist turned entrepreneur (Webinar)
Surendran Narayanan,
RythRx Therapeutics LLC, USA
Contribution of Xenobiotic Transporters to Drug Disposition – Regulatory Case Studies
Jasminder Sahi,
Sanofi, China
GS-6207: A Novel, Potent and Selective First-In-Class Inhibitor of HIV 1 Capsid Function Displays Long Acting Pharmacokinetics and Antiviral Activity in Human
Raju Subramanian,
Gilead Sciences, USA
Tea Break (1030-1045)
Discovery of a novel antibacterial agent to combat Anti-microbial resistance
V. Balasubramanian,
Bugworks, Bangalore
Sponsor Talk-V
Protein affinity, stability and quality analysis using microScale thermophoresis (MST), nanoDSF and Tycho technology
Sivaramaiah Nallapeta,
NanoTemper Technologies India
Young Investigator Presentation-IV
Development of a non-invasive medical device for blood glucose monitoring
Sumedha SK,
M.S.Ramaiah University of Applied Sciences, India
Young Investigator Presentation-V
Intra-organ drug targeting using aptamer-conjugated nanoliposomes to precise hepatocellular carcinoma treatment.
Moumita Dhara,
Jadavpur University, India
Panel discussion
Closing session
Mementoes to Sponsors and raffle card winners announcement
Deepika Dhaware and Sakthi Devan
T. Thanga Mariappan and Jasminder Sahi
Mementoes to participating Institutions with more than 5 attendees
Deepika Dhaware
Vinay H.K. and Bhagwat Prasad
Best Poster (3 awards) and Oral presentation Awards (2 awards)
Abstract committee members,
V. Balasubramanian,
Bugworks, Bangalore
Vote of Thanks
Vinay H.K,
Secretary, SSX, India
BBRC, Syngene International Ltd., India
Lunch (1300-1430)